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Research from Swansea University shows that a single high dose of creatine, typically 15–30 grams, can noticeably enhance cognitive performance during sleep deprivation. This effect includes improvements in memory, reaction time, and problem-solving ability when the brain is under fatigue. Creatine works by increasing the availability of high-energy phosphates in the brain, which supports more efficient cellular energy use. During periods of prolonged wakefulness, this added energy buffer helps prevent the usual decline in mental performance. Overall, these findings suggest that creatine can offer a temporary but meaningful cognitive boost when sleep is lacking.